KMID : 1039420210550020112
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Journal of Pathology and Translational Medicine 2021 Volume.55 No. 2 p.112 ~ p.117
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A study of pathological characteristics and BRAF V600E status in Langerhans cell histiocytosis of Vietnamese children
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Phan Thu Dang Anh
Phung Bao Gia Duong Tu Thanh Hoang Vu Anh Ngo Dat Quoc Trinh Nguyen Dinh The Tran Tung Thanh
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Abstract
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Background: Langerhans cell histiocytosis (LCH) is more common in children than adults and involves many organs. In children, the BRAF V600E mutation is associated with recurrent and high-risk LCH.
Methods: We collected paraffin blocks of 94 pediatric LCH patients to detect BRAF_V600E mutation by sequencing. The relationship between BRAF V600E status and clinicopathological parameters were also critically analyzed.
Results: BRAF V600E mutation exon 15 was detected in 45 cases (47.9%). Multiple systems LCH showed a significantly higher BRAF_V600E mutation rate than a single system (p=.001). No statistical significance was evident for other clinical characteristics such as age, sex, location, risk organs involvement, and CD1a expression.
Conclusions: In Vietnamese LCH children, the proportion of BRAF V600E mutational status was relatively high and related to multiple systems.
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KEYWORD
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Langerhans cell histiocytosis, BRAF V600E mutation, Sequencing
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